看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。7 w# \9 m0 a" h8 R# W7 i& r
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, b: T# f# |/ x$ q# U4 vCurrently available feasibility data for possible combination strategies. / V r6 ^: i& Z4 B
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' _4 v* P+ z- }! |Combination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose
6 ?5 B, ^9 R: g7 HBevacizumab + sunitinib† No + W+ u9 j, T# X1 d
Bevacizumab + temsirolimus Yes 0 d6 O. z5 e i, ?
Bevacizumab + everolimus Yes
& K8 M* a4 R2 |- {# VSorafenib + sunitinib ? , J' K5 A( A& U
Sorafenib + temsirolimus Yes, reduced dose ; w* X: m* S5 D- p' i/ U& b; n
Sorafenib + everolimus Yes, reduced dose 1 p0 }% c( s. [+ C# L1 \" ?! _
Sunitinib + temsirolimus† No ! w: w( y% `7 `, j7 N* s4 e9 ] F) Y2 \
Sunitinib + everolimus ? ! v1 U3 q7 l* v+ O- B, l
Temsirolimus + everolimus ? ; Z1 T* e# `% d4 k) I
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†Led to US FDA warning.
9 c6 }$ E( O0 h+ G1 o) ~/ U?: As yet unattempted combination.( s3 E1 S' O. ^6 Y4 K' W2 ^
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