发给老马备查:
( A, W( I; @ a9 d1 [( Y e- S$ E5 @滴水察海(69304838) 15:23:23) b" f8 C, l# N9 `) ?, Z9 \' T; A8 f
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
: `+ Y( T% z( D! I吉非替尼和S-1连用的依据
# A# d( z# }; Y& a4 \Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
7 S% H1 I7 a$ I4 i% X+ R4 ~0 l是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
3 b3 b7 ? i" W- y; Y这样是不是推理出,耐药后,可以用S-1和培美了?/ ^( o! R- n) [$ M" O( H- w3 I
结论:
1 V' N+ p4 J0 e: b! g如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |